Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as DNA-PK inhibitors

作为dna-pk抑制剂的(s)-n-甲基-8-(1-((2’-甲基-[4,5’-联嘧啶]-6-基)氨基)丙-2-基)喹啉-4-甲酰胺及其氘化衍生物的共晶

Abstract

The present invention relates to compositions and co-crystals each comprising a compound of formula I having the structure: wherein each of R1 and R2 is H or 2H and a co-crystal former selected from adipic acid, citric acid, fumaric acid, maleic acid, succinic acid, or benzoic acid. Also within the scope of this invention are methods of making and using the same.
本发明涉及包含具有如下结构的式I的化合物和共晶成形剂的组合物和共晶,其中R1和R2各自为H或2H,且所述共晶成形剂选自己二酸、柠檬酸、富马酸、马来酸、琥珀酸或苯甲酸。本发明范围内还有制备和使用所述组合物和共晶的方法。

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Patent Citations (2)

    Publication numberPublication dateAssigneeTitle
    WO-2008042639-A1April 10, 2008Irm Llc, Novartis AgComposés et compositions utilisés en tant qu'inhibiteurs de protéine kinase
    WO-2013163190-A1October 31, 2013Vertex Pharmaceutical IncorporatedDna-pk inhibitors

NO-Patent Citations (1)

    Title
    ADAM KASHISHIAN ET AL.: "“DNA-dependent protein kinase inhibitors as drug candidates for the treatment of cancer”", 《MOLECULAR CANCER THERAPEUTICS》

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