一种药物增溶载体及其制备方法和应用

Medicament solubilization carrier and preparation method and application thereof

Abstract

The invention relates to a method for preparing hyaluronic acid amphipathic derivatives of a biodegradable medicament solubilization carrier and application thereof serving as a medicament carrier. The derivatives have amphipathy by introducing hydrophobic alkyl chains and active targeting ligand molecules into a hyaluronic acid skeleton such as folic acid, are self-assembled in water to form polymeric micelles and effectively deliver a medicament to tumor tissues in a targeting mode. The auxiliary material has good safety and low critical micelle concentration, the medicament is wrapped in a hydrophobic core by double actions between a hydrophobic group and the medicament and between a hyaluronic acid molecular chain and the medicament and can be used as an insoluble medicament and a carrier of protein and genic medicaments, and the carrier has high medicament carrying amount, high medicament wrapping rate and good stability and can be used for administration of venous or intramuscular injection and oral path. The preparation method is simple, has mature process, and is suitable for large-scale production.
本发明涉及一种生物可降解的药物增溶载体透明质酸两亲性衍生物的制备方法及其作为药物载体的应用。这类衍生物是通过在透明质酸骨架引入疏水性烷基链和主动靶向配体分子,如叶酸,使其具有两亲性,在水中自组装形成聚合物胶束,并有效地靶向传递药物至肿瘤组织。该辅料安全性好,临界胶束浓度低,通过疏水基团和透明质酸分子链与药物的双重作用将药物包裹于疏水内核。可以作为难溶性药物,蛋白质和基因类药物的载体,载药量高,药物包封率高,稳定性好,可用于静脉或肌肉注射和口服途径给药。本发明制备方法简单,工艺成熟,适用于大规模生产。

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Patent Citations (1)

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    Title
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